Human DJ-1-specific transcriptional activation of the tyrosine hydroxylase gene
نویسندگان
چکیده
From the Graduate School of Agriculture, Hokkaido University, Kita-ku, Sapporo 060-8589, Japan 1 , the Graduate School of Life Science, Hokkaido University, Kita-ku, Sapporo 060-0812, Japan 2 , the Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi University, Chuoh, 409-3898, Japan 3 , the Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812, Japan 4
منابع مشابه
Human DJ-1-specific Transcriptional Activation of Tyrosine Hydroxylase Gene*
Loss-of-function mutation in the DJ-1 gene causes a subset of familial Parkinson disease. The mechanism underlying DJ-1-related selective vulnerability in the dopaminergic pathway is, however, not known. DJ-1 has multiple functions, including transcriptional regulation, and one of transcriptional target genes for DJ-1 is the tyrosine hydroxylase (TH) gene, the product of which is a key enzyme f...
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Loss-of-function DJ-1 mutations have been linked to autosomal recessive early-onset Parikinsonism. However, the putative function of DJ-1 is not completely understood. Previous studies indicate that DJ-1 overexpression results in upregulation of the tyrosine hydroxylase gene. The mechanism by which DJ-1 affects tyrosine hydroxylase expression remains elusive. In the present study, we show that ...
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